Principal Investigator: Dr. Claudia Lucchinetti
Project Title: Synergistic Interactions between Astrocytes,
Neuromyelitis optica (NMO) is a devastating and poorly understood inflammatory demyelinating disease of the central nervous system that resembles multiple sclerosis but has several distinctive characteristics. These differences convinced Mayo Clinic investigators that detailed study of NMO from a fresh perspective might bring new insights to the entire field of multiple sclerosis-like diseases. The Mayo NMO Consortium has coalesced over the past decade as an interactive team of clinical and basic investigators with a common interest in neurological autoimmunity and neuroprotection. The complementary expertise of our consortium (clinical, pathological, immunological, epidemiological and genetic) has spawned a coordinated effort to understand NMO.
The goals of the Mayo NMO Consortium are to:
The consortium is developing a central repository of NMO patient-derived data and biospecimens as the basis for future and ongoing research with national and international collaborators. Infrastructure provided by the Guthy-Jackson Foundation facilitates integration of clinical and basic research activities, including development of novel antibody tests for early identification of and prediction of the course of disease, development of authentic animal models to explore new therapeutic approaches and design of clinical trials to test the efficacy of new therapies.
The Mayo Team members: