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St. George’s: University of London

Marios C. Papadopoulos, MA MD FRCS(SN)

Principal Investigator: Marios C. Papadopoulos, MA MD FRCS(SN)

Project Title: Pathogenesis of Neuromyelitis Optica

The project will address clinically relevant questions in NMO pathogenesis, including why AQP4-IgG damages the CNS but spares other organs, how the pathogenesis of AQP4-IgG negative NMO differs from AQP4-IgG positive NMO, the effect of AQP4-IgG on the placenta with implications for pregnancy, and whether macrophages –the predominant leukocyte in NMO lesions – are beneficial or harmful.

Website: http://www.sgul.ac.uk/research/researchers/l-p/marios-papadopoulos